KeyMolnet Contents are constructed by validation, standardization, extraction, and review of data collected from carefully selected literatures by IMMD scientists. Therefore, KeyMolnet Contents ensure “reliability,” and is thus called “Brain-Curated Contents”.KeyMolnet Contents consist of three core sets of information; “Molecular Network,” “Disease,” and “Drug.”Core Contents:The information of “Pathway” which consists of signal transduction, transcriptional regulation, and metabolic pathways, and “Molecular Relation” is collected from the full text of reviewed articles at the high levels. Thus, it is very reliable and stable.Secondary Contents:The information of “Molecular Relation” is collected from the PubMed abstracts of published papers. Secondary Contents contain more comprehensive and up-to date information.User Contents:User’s experimental and/or hypothetical data can be merged with the KeyMolnet Contents and used as integrated data.Currently, HPRD (Human Protein Reference DatabaseTM) data are available in KeyMolnet as one of the integrated User Contents.


Disease Information covers a broad range of disease areas and is systematically organized.Disease Name, Disease Mediating Molecule、Name and/or Pathological Event Name can easily be retrieved using each of these terms.Disease Mediating Molecule is defined as a molecule associated with a certain disease.Pathological Event is defined as biological phenomena, events and processes in the disease states including symptoms and clinical signs.Molecular networks can also be generated based on information of “Disease,” “Disease Mediating Molecule” and/or “Pathological Event.”“Endoplasmic Reticulum Stress” network based on the “Pathological Event” information.Drug Information The information on Target Molecule and its reference has been compiled from the launched drugs in Japan and US. The information on drug candidates under clinical development and reagents are also included.


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