当社創薬事業に関連する文献
◆ IMD-1041
  • Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.
    Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
    (Mol Vis. 2012;18:2586-97.)
  • Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.
    Tanaka T, Ogawa M, Suzuki J, Sekinishi A, Itai A, Hirata Y, Nagai R, Isobe M.
    (Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45.)
  • Aldosterone-induced kidney injury is mediated by NFκB activation.
    Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M.
    (Clin Exp Nephrol. 2011 Feb;15(1):41-9.)
◆ IMD-0354
  • Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.
    Fuchimoto J, Kojima T, Kobayashi N, Ohkuni T, Ogasawara N, Masaki T, Obata K, Nomura K, Kondoh A, Shigyo T, Himi T, Sawada N.
    (Am J Rhinol Allergy. 2012 Nov-Dec;26(6):433-8.)
  • Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.
    Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
    (Mol Vis. 2012;18:2586-97. Epub 2012 Oct 20.)
  • A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice.
    Hamaya R, Ogawa M, Kobayashi N, Suzuki J, Itai A, Hirata Y, Nagai R, Isobe M.
    (Int Heart J. 2012;53(2):133-8.)
  • IκB kinase-beta inhibitor attenuates hepatic fibrosis in mice.
    Wei J, Shi M, Wu WQ, Xu H, Wang T, Wang N, Ma JL, Wang YG.
    (World J Gastroenterol. 2011 Dec 21;17(47):5203-13.)
  • Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro.
    Zhang W, Li XJ, Zeng X, Shen DY, Liu CQ, Zhang HJ, Xu CB, Li XY.
    (Toxicol Lett. 2012 Mar 7;209(2):107-12.)
  • Regulation of cytochrome P450 4F11 by nuclear transcription factor-κB.
    Bell JC, Strobel HW.
    (Drug Metab Dispos. 2012 Jan;40(1):205-11.)
  • An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells.
    Uota S, Zahidunnabi Dewan M, Saitoh Y, Muto S, Itai A, Utsunomiya A, Watanabe T, Yamamoto N, Yamaoka S.
    (Cancer Sci. 2012 Jan;103(1):100-6.)
  • Involvement of the NF-κB pathway in multidrug resistance induced by HBx in a hepatoma cell line.
    Liu Y, Lou G, Wu W, Zheng M, Shi Y, Zhao D, Chen Z.
    (J Viral Hepat. 2011 Oct;18(10):e439-46.)
  • The role of tumor necrosis factor-α and TNF-α receptors in cerebral arteries following cerebral ischemia in rat.
    Maddahi A, Kruse LS, Chen QW, Edvinsson L.
    (J Neuroinflammation. 2011 Aug 28;8:107.)
  • Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS.
    Forte G, Sorrentino R, Montinaro A, Pinto A, Morello S.
    (Cytokine. 2011 May;54(2):161-6.)
  • The novel NF-κB inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemia.
    Kanduri M, Tobin G, Aleskog A, Nilsson K, Rosenquist R.
    (Blood Cancer J. 2011 Mar;1(3):e12.)
  • Cigarette smoke extract promotes human vascular smooth muscle cell proliferation and survival through ERK1/2- and NF-κB-dependent pathways.
    Chen QW, Edvinsson L, Xu CB.
    (ScientificWorldJournal. 2010 Nov 4;10:2139-56.)
  • Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK.
    Sandhu H, Xu CB, Edvinsson L.
    (Toxicol Appl Pharmacol. 2010 Nov 15;249(1):25-32.)
  • IκB kinase β inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma.
    Ogawa H, Azuma M, Muto S, Nishioka Y, Honjo A, Tezuka T, Uehara H, Izumi K, Itai A, Sone S.
    (Clin Exp Allergy. 2011 Jan;41(1):104-15.)
  • NF-kappaB signaling mediates vascular smooth muscle endothelin type B receptor expression in resistance arteries.
    Zheng JP, Zhang Y, Edvinsson L, Hjalt T, Xu CB.
    (Eur J Pharmacol. 2010 Jul 10;637(1-3):148-54.)
  • A novel NF-κB inhibitor improves glucocorticoid sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors.
    Matsuda A, Tanaka A, Muto S, Ohmori K, Furusaka T, Jung K, Karasawa K, Okamoto N, Oida K, Itai A, Matsuda H.
    (Res Vet Sci. 2010 Dec;89(3):378-82.)
  • Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.
    Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
    (Histochem Cell Biol. 2010 Mar;133(3):339-48.)
  • Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling.
    Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I.
    (Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L197-209.)
  • Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
    Hayakawa Y, Maeda S, Nakagawa H, Hikiba Y, Shibata W, Sakamoto K, Yanai A, Hirata Y, Ogura K, Muto S, Itai A, Omata M.
    (J Gastroenterol. 2009;44(9):935-43.)
  • Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.
    Norden R, Nystrom K, Olofsson S.
    (Glycobiology. 2009 Jul;19(7):776-88.)
  • NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance.
    Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR, Li JJ.
    (Radiat Res. 2009 Jan;171(1):9-21.)
  • Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissues.
    Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H.
    (Spine (Phila Pa 1976). 2008 Nov 1;33(23):2489-94.)
  • Antiallergic and anti-inflammatory effects of a novel I kappaB kinase beta inhibitor, IMD-0354, in a mouse model of allergic inflammation.
    Sugita A, Ogawa H, Azuma M, Muto S, Honjo A, Yanagawa H, Nishioka Y, Tani K, Itai A, Sone S.
    (Int Arch Allergy Immunol. 2009;148(3):186-98.)
  • Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.
    Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S.
    (J Med Dent Sci. 2008 Mar;55(1):49-59.)
  • Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone.
    Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A.
    (Mod Rheumatol. 2007;17(6):459-63.)
  • Down-regulation of alpha-adrenoceptor expression by lipid-soluble smoke particles through transcriptional factor nuclear factor-kappaB pathway.
    Zhang W, Cao YX, He JY, Xu CB.
    (Basic Clin Pharmacol Toxicol. 2007 Dec;101(6):401-6.)
  • Kit: molecule of interest for the diagnosis and treatment of mastocytosis and other neoplastic disorders.
    Patnaik MM, Tefferi A, Pardanani A.
    (Curr Cancer Drug Targets. 2007 Aug;7(5):492-503.)
  • Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.
    Fan M, Ahmed KM, Coleman MC, Spitz DR, Li JJ.
    (Cancer Res. 2007 Apr 1;67(7):3220-8.)
  • Topical application with a new NF-kappaB inhibitor improves atopic dermatitis in NC/NgaTnd mice.
    Tanaka A, Muto S, Jung K, Itai A, Matsuda H.
    (J Invest Dermatol. 2007 Apr;127(4):855-63.)
  • Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction.
    Onai Y, Suzuki J, Maejima Y, Haraguchi G, Muto S, Itai A, Isobe M.
    (Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H530-8.)
  • A novel IkappaB kinase-beta inhibitor ameliorates bleomycin-induced pulmonary fibrosis in mice.
    Inayama M, Nishioka Y, Azuma M, Muto S, Aono Y, Makino H, Tani K, Uehara H, Izumi K, Itai A, Sone S.
    (Am J Respir Crit Care Med. 2006 May 1;173(9):1016-22.)
  • A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition.
    Tanaka A, Muto S, Konno M, Itai A, Matsuda H.
    (Cancer Res. 2006 Jan 1;66(1):419-26.)
  • A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors.
    Tanaka A, Konno M, Muto S, Kambe N, Morii E, Nakahata T, Itai A, Matsuda H.
    (Blood. 2005 Mar 15;105(6):2324-31.)
  • A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
    Kamon J, Yamauchi T, Muto S, Takekawa S, Ito Y, Hada Y, Ogawa W, Itai A, Kasuga M, Tobe K, Kadowaki T.
    (Biochem Biophys Res Commun. 2004 Oct 8;323(1):242-8.)
  • Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.
    Onai Y, Suzuki J, Kakuta T, Maejima Y, Haraguchi G, Fukasawa H, Muto S, Itai A, Isobe M.
    (Cardiovasc Res. 2004 Jul 1;63(1):51-9.)
  • Inhibition of the activation of nuclear factor kappa B to reduce myocardial reperfusion injury and infarct size.
    Thiemermann C.
    (Cardiovasc Res. 2004 Jul 1;63(1):8-10.)
◆ IκB kinase β
  • IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats.
    Orita S, Miyagi M, Kobori S, Gemba T, Ishikawa T, Inoue G, Toyone T, Aoki Y, Eguchi Y, Takahashi K, Ohtori S.
    (Spine J. 2013 Mar;13(3):284-8.)
  • Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats.
    Lennikov A, Kitaichi N, Noda K, Ando R, Dong Z, Fukuhara J, Kinoshita S, Namba K, Mizutani M, Fujikawa T, Itai A, Ohno S, Ishida S.
    (Mol Vis. 2012;18:2586-97. Epub 2012 Oct 20.)
  • Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif.
    Liu X, Sano T, Guan Y, Nagata S, Hoffmann JA, Fukuyama H.
    (PLoS One. 2012;7(8):e42725.)
  • Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS.
    Forte G, Sorrentino R, Montinaro A, Pinto A, Morello S.
    (Cytokine. 2011 May;54(2):161-6.)
  • Aldosterone-induced kidney injury is mediated by NFκB activation.
    Fukuda S, Horimai C, Harada K, Wakamatsu T, Fukasawa H, Muto S, Itai A, Hayashi M.
    (Clin Exp Nephrol. 2011 Feb;15(1):41-9.)
  • IκB kinase β inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma.
    Ogawa H, Azuma M, Muto S, Nishioka Y, Honjo A, Tezuka T, Uehara H, Izumi K, Itai A, Sone S.
    (Clin Exp Allergy. 2011 Jan;41(1):104-15. )
  • Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
    Hayakawa Y, Maeda S, Nakagawa H, Hikiba Y, Shibata W, Sakamoto K, Yanai A, Hirata Y, Ogura K, Muto S, Itai A, Omata M.
    (J Gastroenterol. 2009;44(9):935-43.)
  • Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.
    Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S.
    (J Med Dent Sci. 2008 Mar;55(1):49-59.)
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